Alcohol and Sleep


Alcohol administration increases the concentration of allopregnanolone (AP) in the brain.. AP acts as a neuroactive steroid modulating the inhibitory effects of the neurotransmitter GABA and induces some behavioral effects of alcohol, including relaxation and sleep.
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Alcohol consumption can induce sleep disorders by disrupting the sequence and duration of sleep states and by altering total sleep time as well as the time required to fall asleep (i.e., sleep latency).
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http://www.sleephotline.com/Sleep/categories/Sleep-Management-Tips.html
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People often use alcohol to help induce sleep, as a nightcap. However, it is a poor choice. Alcohol is associated with sleep disruption and creates a sense of nonrefreshed sleep in the morning.

http://www.emedicinehealth.com/insomnia/page2_em.htm
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What are the effects of alcohol on sleep?
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Response from Karl Doghramji, MD Professor of Psychiatry, Jefferson Medical College, Philadelphia, Pennsylvania; Director, Sleep Disorders Center, Thomas Jefferson University, Philadelphia, Pennsylvania
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Alcohol is used extensively as a sleep aid in the general population. In a recent survey,[1] 28% of insomniacs indicated that they had used alcohol to help them fall asleep. Occasional insomniacs used alcohol for an average of 3.6 nights/month, while chronic insomniacs used alcohol for an average of 6.8 nights/month.
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An equal number of occasional insomniacs and chronic insomniacs (67%) described alcohol as an effective or very effective method to induce sleep.When ingested by normal individuals, alcohol leads to a more rapid induction of sleep. It also increases non-REM sleep and reduces REM sleep during the first portion of the night.
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Alcohol is metabolized rapidly and blood concentrations are negligible by the middle of the night for most individuals who have a few drinks prior to bedtime, often resulting in withdrawal symptoms thereafter. These may include shallow sleep and multiple awakenings, REM rebound associated with nightmares or vivid dreams, sweating, and general activation.
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Therefore, although alcohol may be effective in sleep induction, it impairs sleep during the second half of the night and can lead to a reduction in overall sleep time. As a result, it can also be associated with daytime somnolence. It is of interest that alcohol's negative effects on sleep are even observed when it is ingested in the late afternoon.

Humulus Lupulus



The most common use for hops, as you probably already know, is the production of beer. However, its uses go far beyond the making of alcoholic beverages.
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Because of the bitter principles it contains, hops can be used as a strong digestive aid. It also has properties that make it good for relieving tension and as a sleep aid.
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Applications: Antispasmodic/Soporific/Sedative
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Hops are primarily used to reduce tension and aid in sleep.
Sleep Aid: As a sleep aid, hops can be used in a sachet inside of a pillow. The aromatic properties of the herb will help one to fall asleep.
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Tension:
Hops can be taken to help relax the muscles and soothe anxiety.
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Digestive Aid: Hops can help to relax spasms of the digestive system and aid in digestion.
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Description:
Hops are plants that grow throughout Europe and Asia. The female plant has flowers called strobiles that are used for medicinal purposes. They are harvested in early fall. Hops plants are usually tall and can grow as high as 22 feet.
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Dosage:
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As an infusion, drink one cup in the evening to aid sleep.
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As a tincture, take 20 drops in a glass of water 3 times daily for anxiety.
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Take 10 drops with water up to 5 times daily for digestion.
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As a tablet, take for stress or as a sleep aid.
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As a capsule, take 500 mg 3 times daily before meals to help increase appetite.
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A sachet may be made and placed in your pillow to aid in sleep.
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Safety: You should not use hops if you suffer from depression. Consult your health care provider before beginning use of any herb.

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Parts used and where grown
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The hops plant, Humulus lupulus, is a climbing plant native to Europe, Asia, and North America. Hops are the cone-like, fruiting bodies (strobiles) of the plant and are typically harvested from cultivated female plants. Hops are most commonly used as a flavoring agent in beer.
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Active constituents
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Hops are high in bitter substances. The two primary bitter constituents are known as humulone and lupulone.3 These are thought to be responsible for the appetite-stimulating properties of hops. Hops also contain about 1–3% volatile oils. Hops have been shown to have mild sedative properties, although the mechanism is unclear.4 Some herbal preparations for insomnia combine hops with more potent sedative herbs, such as valerian. Hops also contain phytoestrogens that bind estrogen receptors in test tube studies but are thought to have only mild estrogen-like actions.5
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http://www.herbco.com/p-433-hops-whole.aspx


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How to Make a Hops Pillow as a Sleep Aid

Keep your feet warm



Can't Sleep? Warm Your Feet
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Warm feet -- a sign of healthy blood flow -- may help induce restful sleep. So warming up cold feet, such as with an old-fashioned hot water bottle, could help those who have trouble falling asleep.
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Thermoregulation -- the body's heat distribution system -- is strongly linked to sleep cycles. Even lying down increases sleepiness by redistributing heat in the body from the core to the periphery.
Blood flow is a prime method of distributing heat evenly throughout the body. Poor blood flow can cause a reduction in the temperature of the extremities, and the researchers theorized that cold hands and feet might therefore be associated with sleeplessness as well. They authors found that increases in blood flow of in the hands and feet, rather than diet, light or melatonin administration, was the best predictor of the body's readiness for sleep.
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Based on these findings, the authors speculate that any act that increases temperature in the extremities -- such as placing a hot water bottle at the feet, or covering the feet with socks, could help induce sleep more quickly.
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http://articles.mercola.com/sites/articles/archive/2008/01/02/warm-feet.aspx
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There are a few small things to be aware of when it comes to wearing socks. For example, sock layering. When you layer your socks the socks' elastic puts pressure onto your legs, causing poor blood circulation. Even when not layering your socks, if the raw materials used in the socks are like cotton and just absorb moisture and not release, it makes the feet more cold-natured from sweat. As for socks for bedtime use, we recommend ones where the top of the sock is loose fitting, and are made of raw materials that release moisture such as wool or silk.
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Warm feet promote the rapid onset of sleep
Scientists have found that the rapid onset of sleep occurs when the blood vessels in the skin of the hands and feet dilate and cause heat loss at the extremities. This causes the core body temperature to lower. A group of researchers, Drs. Kurt Krauchi, Christian Cajochen, and Anna Wirz-Justice, noted this functional relationship between core body temperature and sleepiness, and hypothesized that the opposite would also be true: the constriction of blood vessels would raise the core body temperature and the human being would come to a state of wakefulness. (Think colder at night and the onset of sleepiness; and warmer in the morning and the onset of wakefulness.)
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Hot bath

Bathing
Pablo Picasso
Oil on canvas
39 cm x62 cm
State Museum of New Western Art, Moscow
1908

Take a bath before going to bed. A bath is much more relaxing than a shower. The warm water raises body temperature that helps you to sleep. Keep the water temperature slightly warmer than your own body temperature. Do not make it too hot as this can make you feeling weak and sweaty. It can also dilate your blood vessels, putting a strain on your heart. Don't stay in a hot bath more than about 15 minutes to minimize the risk of becoming overheated. Add a few drops of essential oils into the bath water. Choose those with soothing and relaxing properties.
Because the temperature drop after a bath occurs more quickly than after exercise, the bath should be taken about two hours before bedtime (baths taken too close to bedtime can make it harder to fall asleep because body temperature may be too elevated).
A hot bath is a great way to relax before bedtime and a good substitute on days when you can't exercise.
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Establish a regular, relaxing bedtime routine such as soaking in a hot bath or hot tub and then reading a book or listening to soothing music.
A relaxing, routine activity right before bedtime conducted away from bright lights helps separate your sleep time from activities that can cause excitement, stress or anxiety which can make it more difficult to fall asleep, get sound and deep sleep or remain asleep.

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http://www.sleepfoundation.org/site/c.huIXKjM0IxF/b.2419247/k.BCB0/Healthy_Sleep_Tips.htm

Gratitude and Sleep

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Gratitude is a vaccine, an antitoxin,and an antiseptic.”— John Henry Jowett
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A third study on gratitude was conducted with adults having congenital and adult-onset neuromuscular disorders (NMDs), with the majority having post-polio disease (PPS).
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Compared to those who were not jotting down their blessings nightly, participants in the gratitude condition reported more hours of sleep each night, spending less time awake before falling asleep, and feeling more refreshed upon awakening.

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The gratitude group also reported more satisfaction with their lives as a whole, felt more optimism about the upcoming week, and felt considerably more connected with others than did participants in the control condition.
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The participants weren’t the only ones believing life was better. According to the researchers, “Spouses of the participants in the gratitude condition reported that the participants appeared to have higher subjective well-being than did the spouses of the participants in the control condition.”
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Gratitude influences sleep through the mechanism of pre-sleep cognitions
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Alex M. Wood , Stephen Joseph, Joanna Lloyd, and Samuel Atkins, of Psychology, University of Manchester, Manchester, England, UK
University of Nottingham, Nottingham, UK
University of Warwick, Warwick, UK
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Abstract

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Objectives

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To test whether individual differences in gratitude are related to sleep after controlling for neuroticism and other traits. To test whether pre-sleep cognitions are the mechanism underlying this relationship.
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Method

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A cross-sectional questionnaire study was conducted with a large (186 males, 215 females) community sample (ages=18–68 years, mean=24.89, S.D.=9.02), including 161 people (40%) scoring above 5 on the Pittsburgh Sleep Quality Index, indicating clinically impaired sleep. Measures included gratitude, the Pittsburgh Sleep Quality Index (PSQI), self-statement test of pre-sleep cognitions, the Mini-IPIP scales of Big Five personality traits, and the Social Desirability Scale.

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Results
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Gratitude predicted greater subjective sleep quality and sleep duration, and less sleep latency and daytime dysfunction. The relationship between gratitude and each of the sleep variables was mediated by more positive pre-sleep cognitions and less negative pre-sleep cognitions. All of the results were independent of the effect of the Big Five personality traits (including neuroticism) and social desirability.

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Conclusion
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This is the first study to show that a positive trait is related to good sleep quality above the effect of other personality traits, and to test whether pre-sleep cognitions are the mechanism underlying the relationship between any personality trait and sleep. The study is also the first to show that trait gratitude is related to sleep and to explain why this occurs, suggesting future directions for research, and novel clinical implications.

htpp://www.sciencedirect.com

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Cultivating Gratitude: An Interview with Robert Emmons, Ph.D.

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Robert Emmons, professor of psychology at the University of California, Davis, is one of the foremost authorities on the topic of gratitude in North America. He is the author of more than sixty research articles and two books, Words of Gratitude: For Mind, Body & Soul (Templeton Foundation Press 2001 - co-authored with Joanna Hill) and, The Psychology of Gratitude (Oxford University Press, 2004).

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He has been studying what makes people happy for nearly twenty years and in this interview, conducted by Thirty Thousand Days Ass't Editor Trudy Boyle, Emmons reveals some of his conclusions about the practice and importance of cultivating gratitude.

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TB: Dr. Emmons, how did you actually get interested in the subject of gratitude?
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RE: Well, actually it came about as somewhat of a fortuitous accident. I was invited to this conference in 1998, and the conference was on virtues — those traits of character that philosophies and religions have considered important for centuries, but psychologists really hadn’t studied very much.

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Some examples are wisdom, hope, love, forgiveness, humility, and gratitude. So each of the people attending this conference were assigned a particular virtue to become the expert on, and to review all the literature and present a one hour talk on what’s known about it and how psychology might advance knowledge of that particular virtue. I was asked to study gratitude. I had studied happiness in graduate school and gratitude has often been seen as one route to happiness — by becoming more grateful and counting your blessings and so forth. I said “sure I’ll do it,” and it is probably one of the most interesting things I’ve ever studied.
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TB: In your research do you find that some people are, by nature, grateful? And, if so, have you discovered anything that you think makes that difference?
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RE: There’s a whole cluster of related characteristics that seem to go together — things like optimism, hope, gratitude, and happiness. Some of this, I would guess, is genetically determined. Some of it is going to be based upon early life experiences and positive relationships with other people. Very little of it, interestingly, seems to depend upon circumstances. So there are just these ways of framing life experiences that transcend good or bad things that are happening to a person. There’s a cluster of positive characteristics and then there’s another set of characteristics which block those positive characteristics. A sense of entitlement, or deservingness, is something that’s going to block this recognition that other people are partly responsible for the good things that happen to us. When I take all the credit for the good things that happen to me it’s going to be hard to feel a sense of indebtedness or sense of gratefulness in life.
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TB: What would you consider to be a common, but incorrect assumption about your work?
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RE: Sometimes there’s an assumption that if one is grateful then almost by definition one is less autonomous or less self motivated. That gratitude leads to complacency, you know, accepting one’s situation no matter what it is (unhealthy, abusive, etc) and not doing anything about it. I’ve never seen a case where that’s happened. We don’t find evidence of that passivity in the research.
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TB: I’m interested in practices that will help instill a sense of gratitude in people. Have you found any practices that will help shift a person’s perspective to be more appreciative?
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RE: What we do in our research is have people keep gratitude journals on a regular, daily basis. This process of writing, just putting it on paper, helps people focus, and people report that it helps them to think about things a little differently than they had before. People start to think about things in their lives as benefits or as gifts that are given to them, and not necessarily things they have earned or deserved.
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TB: One thing I do when I introduce Naikan to people, is to make a distinction between a gratitude journal and noticing the ways that we’re supported whether we’re grateful or not.
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RE: That’s right. We have tried to get people thinking along the lines of specific others, and specific events. In other words the source, and what that person, or it could be God for instance, has provided to you. Otherwise the gratitude journal could just be a happiness journal – stuff people feel good about, not necessarily specific things they’ve been given by other people.
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TB: You included Naikan in your book as a practice to cultivate gratitude. How did you discover Naikan?
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RE: Well I was interested in trying to understand why the practice of gratitude was not represented in any sort of formal psychotherapy. And so I just started doing some searches and came across Naikan as a therapy developed in Japan that had gratitude as well as guilt at its core.
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TB: Would you say that the kind of guilt that Naikan may stimulate is a healthy guilt?
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RE: Absolutely – a beneficial guilt. Psychologists tend to have a negative spin on guilt, you know. You shouldn’t have guilt, it’s debilitating and so forth. But it can be very restorative as well.
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TB: What has changed in the last 50 years as we’ve become a more secular and richer society?
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RE: I think of gratefulness as really anchored in spirituality. And so a secular perspective is going to tend to erode that sense of gratefulness. Also, with increasing expectations and material comfort one tends to be less reflective. It goes with the territory, and it makes it difficult to spend the time to acknowledge where things come from and the people to whom one is indebted.
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TB: Do you have any recommendations that you give to parents or teachers who want to help instill a sense of gratitude in children?
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RE: I think practices that people have known about for a long time are the ones that are going to work. Like being a role model, expressing gratefulness oneself as a parent, writing thank you letters to relatives, teachers and those who have provided benefits. Very concrete things, like gratitude prayers within one’s tradition at mealtime and bedtime – very concrete.
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TB: Are you continuing on with your research on gratitude?
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RE: We are. We are trying to look at some of the consequences of gratefulness. Most of the work I’ve done I’ve looked at the personal benefits in terms of happiness, and health benefits. We’re going to start a study where we look at married couples and see if gratefulness or keeping a gratitude journal impacts on the marital relationship — marital quality.
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TB: What do you consider to be the merit of selflessness? When you think about people like Schweitzer, Gandhi, Mother Teresa, or others who really gave themselves away. They really led a selfless life, for the benefit of other people.
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RE: In the cases of Mother Teresa and others that are talked about in the literature, one of the qualities that tend to motivate them is gratitude. They don’t seem to fit the usual conception of gratitude where you see a benefit and then you’re grateful. They felt grateful for the opportunity to help, as opposed to receiving help. They knew there was some benefit for them in developing compassion or whatever it was, and so they didn’t need to receive gratefulness from the people they helped. I think what enabled them to persist under stressful circumstances was just the ability to be helpful, which created in them a sense of gratitude, a sense of purpose, that they wouldn’t otherwise have had.
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TB: Is there anything else that you would like to add?
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RE: I think it’s important to stress that gratitude is really a choice. It doesn’t depend upon circumstances or genetic wiring or something that we don’t have control over. It really becomes an attitude that we can choose that makes life better for ourselves and for other people. I think about it as the best approach to life and I gave a talk this past summer where the title was, “Gratitude Is the Best Approach To Life.” At the time it seemed a little presumptuous, but the more I think about it, I really think the title is true. When things go well gratitude enables us to savor things going well. When things go poorly gratitude enables us to get over those situations and to realize they are temporary.
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TB : I think that’s a great title for your next book.

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RE: I’ll use it.

http://www.todoinstitute.com


Valerian


Valerian

SUSAN HADLEY, M.D., Middlesex Hospital, Middletown, Connecticut JUDITH J. PETRY, M.D., Vermont Healing Tools Project, Brattleboro, Vermont

Valerian is a traditional herbal sleep remedy that has been studied with a variety of methodologic designs using multiple dosages and preparations. Research has focused on subjective evaluations of sleep patterns, particularly sleep latency, and study populations have primarily consisted of self-described poor sleepers.
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Valerian improves subjective experiences of sleep when taken nightly over one- to two-week periods, and it appears to be a safe sedative/hypnotic choice in patients with mild to moderate insomnia. The evidence for single-dose effect is contradictory. Valerian is also used in patients with mild anxiety, but the data supporting this indication are limited. Although the adverse effect profile and tolerability of this herb are excellent, long-term safety studies are lacking. (Am Fam Physician 2003;67:1755-8.
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The root of valerian, a perennial herb native to North America, Asia, and Europe, is used most commonly for its sedative and hypnotic properties in patients with insomnia, and less commonly as an anxiolytic. Multiple preparations are available, and the herb is commonly combined with other herbal medications.
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This review addresses only studies that used valerian root as an isolated herb. As with most herbal products available in the United States, valerian root extracts are not regulated for quality or consistency. Independent testing laboratories (such as www.consumerlab.com) generally use valeric acid content as a marker for pharmacologic activity and represent one source for reliable information to support product choice.
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Pharmacology
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The chemical composition of valerian includes sesquiterpenes of the volatile oil (including valeric acid), iridoids (valepotriates), alkaloids, furanofuran lignans, and free amino acids such as g-aminobutyric acid (GABA), tyrosine, arginine, and glutamine. Although the sesquiterpene components of the volatile oil are believed to be responsible for most of valerian's biologic effects, it is likely that all of the active constituents of valerian act in a synergistic manner to produce a clinical response.1
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Research into physiologic activity of individual components has demonstrated direct sedative effects (valepotriates, valeric acid) and interaction with neurotransmitters such as GABA (valeric acid and unknown fractions).
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Uses and Efficacy
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SEDATIVE/HYPNOTIC
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Several clinical studies have shown that valerian is effective in the treatment of insomnia, most often by reducing sleep latency. A double-blind, placebo-controlled trial4 compared a 400-mg aqueous extract of valerian and a commercial valerian/hops preparation with placebo of encapsulated brown sugar. A total of 128 volunteers completed a subjective study evaluating the effects of single doses of each test compound taken in random order on sleep latency, sleep quality, sleepiness on awakening, night awakenings, and dream recall. Valerian extract demonstrated statistically significant improvement over placebo in sleep latency and sleep quality. There was no difference between valerian extract and placebo in the other two parameters. The commercial valerian/hops preparation resulted in no changes in sleep latency, sleep quality, or night awakenings, and an increase in sleepiness on awakening. No information on the preparation of the commercial product was available, so the reasons for the lack of effect are unknown.
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Examination of the study subgroups showed that the positive effects of valerian extract on sleep were most significant in older male patients who considered themselves to be poor sleepers, female poor sleepers, younger poor sleepers, smokers, and those who habitually have lengthy sleep latencies. Subjects who rated themselves as habitually good sleepers were largely unaffected by the valerian extract.
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In a double-blind study,5 eight subjects who described themselves as having lengthy sleep latency wore a wrist activity meter and provided subjective sleep ratings in a study of the effects of valerian. Participants received either a 450- or 900-mg dose of an aqueous extract of valerian root or placebo. Single-dose (450 and 900 mg) valerian extract resulted in significant decreases in measured and subjective sleep latency and more stable sleep during the first quarter of the night, with no effect on total sleep time. The 900-mg dose produced increased sleepiness on awakening compared with placebo.
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A randomized, placebo-controlled, double-blind, cross-over study6 involving 16 patients with insomnia confirmed by polysomnography demonstrated no effects on sleep efficiency after a single 600-mg dose of the valerian extract Sedonium, while multiple doses over 14 days resulted in significant improvement in parameters of slow-wave sleep measured by polysomnography. There was a nonsignificant trend toward reduced subjective sleep latency after the long-term valerian treatment.6
Several studies have shown valerian's efficacy in patients who do not have sleep disturbances. A small study7 of 10 patients at home and eight patients at a sleep laboratory who received two different dosages (450 and 900 mg) of an aqueous extract of valerian root demonstrated that both groups experienced a greater than 50 percent improvement in sleep latency and wake time after sleep onset. The efficacy results were based on questionnaires, self-rating scales, and nighttime motor activity.
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Electroencephalographic recordings in the laboratory section of the study showed no differences in efficacy between valerian and placebo, and data indicated a dose-dependent mild hypnotic effect of the valerian extract.7
A recent systematic review8 of randomized trials of the effect of valerian on patients with insomnia included reports in all languages.8 [Evidence level B, systematic review of studies other than randomized controlled trials (RCTs)] The authors found nine randomized, double-blind, placebo-controlled trials that met the inclusion criteria. Two studies9,10 showed improvement in sleep-related parameters in patients with insomnia who received repeated administration over two to four weeks. Another study11 demonstrated effects after days 1 and 8 in slow-wave sleep, but no effect on subjective measures of sleep. Results were contradictory in six acute-dose studies.4,5,7,12,13 The authors pointed out the wide variety of methodologies used in the studies, and the lack of attention to factors such as randomization, blinding, compliance, withdrawal, confounding variables, diagnostic criteria, and statistical analysis. They concluded that evidence for valerian in the treatment of insomnia is inconclusive, and that more rigorous trials are necessary.
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A recent multicenter14 (RCT) compared a 600-mg dose of the valerian extract Sedonium with 10 mg of oxazepam over a six-week period in 202 patients who were diagnosed with non-organic insomnia. The two agents were equally effective in increasing sleep quality as measured by the Sleep Questionnaire B (SF-B), and these results were confirmed by subscales of the SF-B, the Clinical Global Impression Scale, and the Global Assessment of Efficacy. Mild to moderate adverse events occurred in 28.4 percent of patients receiving the valerian extract and 36.0 percent of patients taking oxazepam.
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Anxiolytic

Traditional herbalists have used valerian as an anxiolytic, frequently in combination with other herbal preparations such as passion flower and St. John's wort. There is a minimal amount of scientific data confirming this indication for valerian. One randomized, double-blind, placebo-controlled trial15 compared valerian (100 mg) with propranolol (20 mg), a valerian-propranolol combination, and placebo in an experimental stress situation in 48 healthy subjects. Unlike propranolol, valerian had no effect on physiologic arousal but significantly decreased subjective feelings of somatic arousal.
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In a recent preliminary, randomized, double-blind, placebo-controlled trial,16 36 patients with a diagnosis of generalized anxiety disorder were treated with placebo, diazepam in a dosage of 2.5 mg three times daily, or valerian extract in a dosage of 50 mg three times daily (80 percent dihydrovaltrate, 15 percent valtrate, and 5 percent acevaltrate; BYK-Gulden, Lomberg, Germany) for four weeks. Dosage was regulated at one week if an interviewing psychiatrist deemed an increase or decrease necessary. Although the study was limited by a small number of patients in each group, relatively low dosages of the active agents, and a short duration of treatment, the authors found a significant reduction in the psychic factor of the Hamilton Anxiety Scale (HAM-A) with diazepam and valerian.
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Another RCT17 compared 120 mg of kava (LI 150), 600 mg of valerian (LI 156), and placebo taken daily for seven days in relieving physiologic measures of stress induced under laboratory conditions in 54 healthy volunteers. Valerian and kava, but not placebo, significantly decreased systolic blood pressure responsivity, heart rate reaction, and self-reported stress. (note: "LI 156" is an identification number referring to the specific herb and the manufacturer; in this case, Lichtwer Pharma UK, Ltd.)
Contraindications, Adverse Effects, Interactions
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Valerian is listed by the U.S. Food and Drug Administration as a food supplement and is, therefore, not subject to regulatory control beyond labeling requirements. According to Commission E monographs,18 there are no contraindications to valerian. Reported adverse effects of valerian are rare. In a 14-day, multiple-dose study6 of 16 patients, there were only two adverse events (migraine and gastrointestinal effects) in patients receiving valerian compared with 18 events in patients receiving placebo. A randomized, controlled, double-blind study19 of 102 subjects evaluated reaction time, alertness, and concentration the morning after using valerian root extract (600 mg, LI 156) and found no negative effect in single- or repeated-dose administrations of valerian. Only one adverse effect (dizziness) was attributed to the valerian extract.
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No evidence of potentiation of valerian effects by concomitant ingestion of alcohol has been found in animal and human studies, but the combination should still be avoided.1,20 Valerian may potentiate the sedative effects of barbiturates, anesthetics, and other central nervous system depressants.21 One case report22 suggests that sudden cessation of long-term high dose valerian therapy (530 mg to 2 g, five times daily) may result in withdrawal symptoms similar to those occurring with benzodiazepine use. Perhaps because of the poorly defined effects of valerian on GABA neurotransmission, valerian appears to attenuate benzodiazepine withdrawal symptoms in animals and humans.
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Dosage
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Based on the reviewed studies, the effective dosage of valerian root extract for treatment of insomnia ranges from 300 to 600 mg. An equivalent dose of dried herbal valerian root is 2 to 3 g, soaked in one cup of hot water for 10 to 15 minutes.25 The product should be ingested 30 minutes to two hours before bedtime.
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Final Comment
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Valerian is a safe herbal choice for the treatment of mild insomnia and has good tolerability. Most studies suggest that it is more effective when used continuously rather than as an acute sleep aid; more rigorous studies are needed to confirm these results. A potential advantage of valerian over benzodiazepines is the lack of sleepiness on awakening when used at the recommended dosages. Valerian also may be helpful in weaning patients with insomnia from benzodiazepines.
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Chamomile and Sleep

What is chamomile?
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Chamomile is an herb that people have used for centuries. People in the United States probably know it as tea to calm an upset stomach or to help with sleep.
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Two types of chamomile are used for good health: German chamomile (Matricaria retutica) and Roman (or English) chamomile (Chamaemelum nobile).
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Botanical:
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Matricaria recutita (also known as Matricaria chamomilla) Family: Compositae (daisy) - Asteraceae (aster/sunflower) Other common names: German Chamomile, Hungarian Chamomile, Mayweed, True Chamomile, Wild Chamomile, Childbed Flower
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Relax and enjoy the calming effects of Chamomile. If you suffer from insomnia, stress and anxiety, this natural sedative acts as a tonic to soothe your nerves, induce sleep, help calm colitis and improve digestion. Help support the gastrointestinal tract and ease a nervous stomach with Chamomile, the most gentle of the ancient herbs that is still popular today.
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Disclaimer:The information presented herein by Herbal Extracts Plus is intended for educational purposes only. These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.
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History
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The Egyptians dedicated Chamomile to the sun and worshiped it above all other herbs, while Greek physicians prescribed it for fevers and female disorders. Dioscorides and Pliny recommended it to cure headaches and illnesses affecting the liver, kidneys and bladder, and in the ancient Anglo-Saxon manuscript, the Lacnunga, "maythen" is called one of the Nine Sacred Herbs. There are a number of varieties of Chamomile, which is a hardy evergreen perennial of the sunflower family that grows in herb gardens worldwide for its aromatic and medicinal qualities. It usually grows in temperate regions, and since the seeds require open soil to survive, it often grows near roads, around landfills and in cultivated fields as a weed. This beautiful, fragrant herb, which was a favorite aromatic strewing blossom, has been inhaled as snuff or smoked to relieve asthma and cure insomnia.
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Europeans have been using it for nearly four centuries as a remedy for backache, neuralgia and arthritis. Among the components of Chamomile are essential oils (chamazulene, alpha-bisabolol, azulene ), beta-carotene, p-coumaric acid, tannic acid, a glucoside, coumarin, flavonoids (quercetin, rutin, apigenin, luteolin, apigetrin and apiin), scopoletin, triterpene hydrocarbons, thymol, boron, calcium, choline, essential fatty acids, folate, inositol, iron, magnesium, manganese, phosphorus, potassium, selenium, sulfur, zinc, B-vitamins and vitamins A, C, E and K. The herb also includes the amino acid, tryptophan, which has been used for insomnia since the 1600s. Chamomile is a valued cosmetic, as well as medicinal herb and is indispensable in every home.
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Beneficial Uses:
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Chamomile is a natural sedative that has a long history of use as a tranquilizer. Modern science claims that it does indeed soothe frayed nerves, because it actually slows down the central nervous system. As a calmative, it is said to be helpful in treating Attention Deficit Disorder (ADD).
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This wonderfully soothing tonic is excellent for promoting good digestion and helping the gastro-intestinal canal. Chamomile is helpful in treating irritable bowel syndrome, colitis, dyspepsia, gas, travel (motion) sickness, diarrhea and nervous stomach. As an antispasmodic, it helps to relieve stomach cramps. Antispasmodic activity has been documented for both the flavonoid and bisabolol constituents in Chamomile.
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Chamomile has a relaxing effect on the body, and it has been used for centuries to treat insomnia.
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It has also been given to restless children and is said to decrease nightmares in both children and adults when taken before bedtime. Its overall soothing effect has been used as a remedy for teething complaints in infants, as well as a treatment of such common childhood ailments as stomach cramps, middle-ear infections and diarrhea.
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As an "anodyne," Chamomile is used to relieve pain, and traditional herbalists have long recommended it for the pain of backache, neuralgia, rheumatism, headache and arthritis.
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Chamomile contains apigenin, a chemical that prevents the production of proteins that allow malignant cells from anchoring to new sites and counters the inflammatory reactions necessary for new diseased growths to gain blood supplies. Moreover, anti-inflammatory activity has also been documented for the alpha- bisabolol compound.
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Chamomile possesses antioxidant and antiseptic qualities. Evidence indicates that its use neutralizes certain germs and prevents infection, including staph and strep toxins. As an antifungal, it combats Candida albicans and other yeast infections.
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Chamomile is an emmenagogue, an agent that helps to bring on menstruation and regulate its flow. Back in the days when women suffered from the mysterious condition called "the vapors," Chamomile was administered to relieve "hysterical and nervous affections" - actually meaning nervous stomach, menstrual cramps and other common problems related to stress.
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Used internally and externally, Chamomile is a staple of herbal medicine and cosmetics. It is included in shampoos to lighten and condition fair hair, and Chamomile tea is often served in beauty salons to relax facial muscles. Chamomile has been known to whiten skin, soothe sunburn, windburn, eczema and other skin irritations and has also been used as an eye bath and tea bag compress to reduce inflammation and eliminate fatigue. It has also been applied to the skin to treat hemorrhoids, swollen and painful breasts, wounds, rashes and leg ulcers.
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Links to Camomile

WebMD
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German chamomile is used and studied the most. A German governmental organization (Commission E) has approved its use on the skin to reduce swelling and fight bacteria and as a tea or dietary supplement for stomach cramps.
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You can buy chamomile as dried flower heads, an infusion (tea), liquid extract, tinctures (concentrated in alcohol), and in creams and ointments.
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What is chamomile used for?
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People use German chamomile to treat irritation from chest colds, slow-healing wounds, abscesses, gum inflammation, colic, and skin conditions such as psoriasis, eczema, chickenpox, and diaper rash. For these conditions, you use chamomile in an infusion or bath, or as a tincture, which is a concentrated extract mixed with alcohol. People use Roman chamomile as a tea to treat an upset stomach, sleeping problems, or menstrual pain.
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Limited studies have been done on chamomile.
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Is chamomile safe?
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The pollen found in chamomile preparations may cause allergic reactions. If you are allergic to ragweed pollen, you may not be able use chamomile. Chamomile may interfere with blood thinners (anticoagulants).
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The U.S. Food and Drug Administration (FDA) does not regulate dietary supplements in the same way it regulates medicine. A dietary supplement can be sold with limited or no research on how well it works.
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Always tell your doctor if you are using a dietary supplement or if you are thinking about combining a dietary supplement with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a dietary supplement. This is especially important for women who are pregnant or breast-feeding.
When using dietary supplements, keep in mind the following:
Like conventional medicines, dietary supplements may cause side effects, trigger allergic reactions, or interact with prescription and nonprescription medications or other supplements you might be taking. A side effect or interaction with another medication or supplement may make other health conditions worse.
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The way dietary supplements are manufactured may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of supplement that you buy in health food or grocery stores may not be the same as the form used in research.
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Other than for vitamins and minerals, the long-term effects of most dietary supplements are not known.
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